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February 22, 2023

[PubMed] [Google Scholar]. the disease occurring in association with FFA, it is feasible that lupus and LPP may occur as an overlap syndrome. This case underscores the importance of multiple biopsies and the role of direct immunofluorescence in disclosing more than one pathology in the follow-up of patients with scarring alopecia. reported a male with associated generalized hair loss, thus reinforcing the concept of expansion of FFA to peripheral body sites.[8] Although our findings of lupus erythematosus may be coincidental or represent a of the disease, it is feasible that lupus and LPP may overlap, in a similar fashion to a previously described lupus and lichen planus overlap syndrome.[10] Table 1 Frontal fibrosing alopecia in men Open in a separate window Gaffney em et al. /em [11] in their study reported the occurrence of FFA with discoid lupus LDN-192960 hydrochloride erythematosus in a 69-year-old Caucasian woman. In contrast to our case, the reported patient was female, had a known background history of lupus, and distribution of the scalp hair loss sites did not overlap. Although LPP and lupus may share similar histopathological findings, direct immunofluorescence was helpful in our case for LDN-192960 hydrochloride detecting the presence of lupus overlap. Whilst this is the ninth case of biopsy-proven FFA in a man, it is unique, as, to our knowledge, it Mouse monoclonal to CD15.DW3 reacts with CD15 (3-FAL ), a 220 kDa carbohydrate structure, also called X-hapten. CD15 is expressed on greater than 95% of granulocytes including neutrophils and eosinophils and to a varying degree on monodytes, but not on lymphocytes or basophils. CD15 antigen is important for direct carbohydrate-carbohydrate interaction and plays a role in mediating phagocytosis, bactericidal activity and chemotaxis is the first description of FFA with coexisting lupus in the male population. Footnotes Source of Support: Nil Conflict of Interest: None declared. REFERENCES 1. Kossard S. Postmenopausal frontal fibrosing alopecia. Scarring alopecia in a pattern distribution. Arch Dermatol. 1994;130:770C4. [PubMed] [Google Scholar] 2. Faulkner CF, Wilson NJ, Jones SK. Frontal fibrosing alopecia associated with cutaneous lichen planus in a premenopausal woman. Australas J Dermatol. 2002;43:65C7. [PubMed] [Google Scholar] 3. Chew AL, Bashir SJ, Wain EM, Fenton DA, Stefanato CM. Expanding the spectrum of frontal fibrosing alopecia: A unifying concept. J Am Acad Dermatol. 2010;63:653C60. [PubMed] [Google Scholar] 4. Stockmeier M, Kunte C, Sander CA, Wolff H. Kossard frontal fibrosing alopecia in a man [German] Hautarzt. 2002;53:409C11. [PubMed] [Google Scholar] 5. Kossard S, Shiell RC. Frontal fibrosing alopecia developing after hair transplantation for androgenetic alopecia. Int J Dermatol. 2005;44:321C3. [PubMed] [Google Scholar] 6. Nusbaum BP, Nusbaum AG. Frontal fibrosing alopecia in a man: Results of follicular unit test grafting. Dermatol Surg. 2010;36:959C62. [PubMed] [Google Scholar] 7. Ramaswamy P, Mendese G, Goldberg LJ. Scarring alopecia of the sideburns: A unique presentation of frontal fibrosing alopecia in men. Arch Dermatol. 2012;148:1095C6. [PubMed] [Google Scholar] 8. Chen W, LDN-192960 hydrochloride Kigitsidou E, Prucha H, Ring J, Andres C. Male frontal fibrosing alopecia with generalised hair loss. Australas J Dermatol Online. 2012 Nov 29; [PubMed] [Google Scholar] 9. Dlova NC, Goh CL. Frontal fibrosing alopecia in an African man. Int J Dermatol. 2013 [Epub ahead of Print] [PubMed] [Google Scholar] 10. Inal?z HS, Chowdhury MM, Motley RJ. Lupus erythematosus/lichen planus overlap syndrome with scarring alopecia. J Eur Acad Dermatol LDN-192960 hydrochloride Venereol. 2001;15:171C4. [PubMed] [Google Scholar] 11. Gaffney DC, Sinclair RD, Yong-Gee S. Discoid lupus alopecia complicated by frontal fibrosing alopecia on a background of androgenetic alopecia. Br J Dermatol. 2013;169:217C8. [PubMed] [Google Scholar].